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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person additionally had polycythemia, likely secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the proper coronary artery. Physicians and sufferers should concentrate on the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
Geolocation Api
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Privateness Detection Api
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Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be useful in sufferers with angina , have higher ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in men with established coronary artery disease . Therefore, an interplay of endogenous elements of the patient’s danger profile as properly as the testosterone dosing may be issues of whether or not antagonistic events happen.
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Erythrocytosis has been reported as a possible effect of testosterone, which may be useful in patients with anemia. The biggest threat of erythrocytosis happens with injectable forms of testosterone in contrast with transdermal preparations, especially in supraphysiologic doses. An increase of up to 44% of the baseline hematocrit has been reported .
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Rhoden EL, Morgentaler A. Risks of testosterone-replacement remedy and recommendations for monitoring. Testosterone substitute in hypogonadal men with angina improves ischaemic threshold and quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone improve human platelet thromboxane A2 receptor density and aggregation responses.